Causes and Symptoms of Stevens Johnson Syndrome

The cause of Stevens Johnson Syndrome has researchers debating. While it is difficult to pinpoint the exact cause of this serious disorder, many researchers and doctors agree that it is related to an adverse drug reaction caused by an allergy to the medication.

SJS has recently been linked to popular prescription and over the counter medications, including ibuprofen, amoxicillin, tetracycline and non-steroidal anti-inflammatory's (NSAIDs). Bextra, a popular painkiller used to treat arthritis, was withdrawn from the market by the Food and Drug Administration in April 2005 when it was linked to Stevens Johnson Syndrome. The FDA also warned consumers about the link between SJS and Children's Motrin after children who took the medicine developed the painful disorder leading to skin lesions, blindness, and death.

Stevens Johnson Syndrome is believed to be related to two other skin blistering diseases, Erythema Multiforme (EM) and Toxic Epidermal Necrolysis (TEN). Some doctors believe that SJS is actually a severe form of EM, because of the similar symptoms. Stevens Johnson Syndrome is likewise related to TEN, which is a more serious skin disease. In fact, some research has shown that SJS sufferers may develop TEN if the allergic reaction progresses or if the medication is continued.

Stevens Johnson Syndrome is commonly identified by blisters and lesions on the skin and mucous membranes, although there are a variety of painful and debilitating symptoms that may emerge as well. The skin may also begin to peel, some cases reporting up to 30% skin loss.

The symptoms of Stevens Johnson Syndrome usually begin to appear within 1-4 weeks following the drug reaction. In most cases, the disease begins with a high fever and flu like symptoms before progressing into more severe problems.

The following is a list of symptoms associated with Stevens Johnson Syndrome.

• Skin lesions and blisters
• Skin erosion in which layers of the skin will peel off
• Mucous membrane lesions
• Rash and blisters in the mouth or throat
• Swelling of mouth, throat and eyes
• Blisters in the anal and genital regions
• Conjunctivitis with redness and blistering of the eyes (commonly referred to as pink eye)
• Iritis with inflammation of the eye's iris
• Vision problems, including partial or complete blindness

While treatment of Stevens Johnson Syndrome varies greatly with the progression of the disease, treatment goals are to control the pain and prevent infection. For milder symptoms, such as skin blistering and rash, antihistamines and topical creams are used to control itching and burning. Patients may also use anesthetics to reduce the swelling of the throat and mouth to ease the pain of eating and drinking. In severe cases, hospitalization is required to control inflammation. Treatment may be rendered at a burn unit or intensive care unit.

Serious cases of Stevens Johnson Syndrome will lead to blindness, permanent scarring, and death. If you or someone you love has suffered from Stevens Johnson Syndrome due to an adverse drug reaction, you may be able to file a claim against the manufacturer or company that produces the medication. Bisnar & Chase, LLP have helped victims of serious injury since 1978. Let our experienced, successful lawyers help you recover damages for your losses and suffering.